Subjective Pathologic Estimates of Viable Tumor in Ablated Hepatocellular Carcinomas (HCC) are Adequate for Routine Practice and for Radiology/Pathology Correlation Studies
JA Hanson, A Van Dyke, J Gibson, ME Robert, D Jain, and KA Mitchell
Department of Pathology, Yale School of Medicine, New Haven, CT, USA
BACKGROUND
The goal of ablating hepatocellular carcinoma (HCC) is to induce complete tumor necrosis. Several studies have reported poor radiology/pathology correlation when evaluating treatment effect, however, no study has compared the viable tumor (VT) percentages to better define the degree of correlation. In addition, the pathologic methods used to assess VT in ablation cavities (AC) in prior studies are poorly described. The aim of this study was to compare subjective and objective estimates of the percentage of viable tumor (PVT) in ablated HCCs to determine if subjective estimates are reliable. In addition, we undertook our own correlation study to determine how well radiologic PVT estimates correlate with pathologic PVT estimates and what factors may influence this correlation.
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