No. Mutated c-myc is found in many cancers leading to constitutive activation. of many genes involved in cell proliferation.
Which of the following is a tumor supressor.
No. Only one is a tumor supressor
No. Epidermal Growth Factor Receptor (EGFR) is upregulated or constitutively activated by mutation in a number of epithelial derived cancers. Overexpression of active EGFR leads to mitogenesis
No. ras (K, H) is a small G protein involved in translating the signals of certain growth factor receptors into downstream signals for mitogenesis. In its mutated state it is constitutively active.
Yes. p53 induces cell cycle arrest and apoptosis. Both alleles are frequently mutated in tumors cells permitting unrestricted tumor growth.
